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Bmfoxo基因调控家蚕寿命的分子机制研究

WebApr 1, 2024 · In addition, the expression of BmFoxO was altered, and it was found that reduced expression of BmFoxO (dsBmFoxO) downregulated the expression of BmPEPCK-2 and increased the viral fluorescence and content in silkworm embryonic cell line BmE cells, and vice versa. BmFoxO could upregulate the expression of BmPEPCK-2 by binding to … Web主要获得了如下研究结果:1.家蚕寿命与BmFoxO基因表达量间的关系家蚕各品系的发育时长不同,寿命也存在差异。. 从家蚕基因库中选取一组品系进行寿命统计,并对其中的三个代 …

The FOXO Transcription Factor Controls Insect Growth and …

WebSep 25, 2015 · Silkworm contains several distinct proteins that have anti-apoptotic activities in mammalian and insect cells. Although the characteristics of 30K proteins have been well investigated, those of SPs (Storage Proteins) have not been examined. In this article, an anti-apoptotic effect of SP1 was investigated in HeLa cell apoptosis. SP1, a type of insect … WebDepletion of BmFOXO induced the expression of genes coding for JH degradation enzymes suggesting that FOXO is likely involved in repression of JH degradation genes, and … dorfkrug kaprun https://mlok-host.com

The FOXO transcription factor controls insect growth and …

WebOct 1, 2024 · BmFoxO-egfp-baculovirus or egfp-baculovirus (control) were injected into the female larvae hemocoel on the first day of the fifth instar at the same virus titer (5000 … WebOct 1, 2024 · Since conserved insulin signaling pathway is involved in carbohydrate metabolism (Cohen, 2006), we investigated whether the expression of B. mori insulin receptor (BmInR) and BmFoxO, the two key factors of the insulin-like signaling pathway (ILS) responds to nutrition deprivation.The results demonstrated that both BmInR and … In this study, we demonstrated that the BmFoxO gene participates in the regulation of the cell cycle induced by 20-Hydroxyecdysone (20E) in BmN-SWU1 cells. The 20E blocks the cell cycle in the G2/M phase through the ecdysone receptor (EcR) and inhibits DNA replication. The 20E can promote BmFoxO gene expression. rac 37

BmFoxO基因调控家蚕寿命的分子机制研究 - CNKI

Category:E2F4 regulates the cell cycle and DNA replication in the silkworm ...

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Bmfoxo基因调控家蚕寿命的分子机制研究

陈根：FOXO3，长寿人群的长寿基因 - 知乎 - 知乎专栏

Webknocking out BmFOXO using the transgene-based CRISPR/ Cas9 system. BmFOXO mutants showed a significant growth delay from the second larval instar and skipped the last molt, resulting in precocious metamorphosis after only four larval instars (trimolter), although the entire developmental time of WebJun 18, 2024 · Forkhead box O (FoxO) is a downstream transcription factor of the insulin-signaling pathway, which plays vital roles in the growth and metabolism of organisms. In this study, BmFoxO was overexpressed in BmE cells, in which proliferation was inhibited and apoptosis was increased. The transgenic vector overexpressing BmFoxO was …

Bmfoxo基因调控家蚕寿命的分子机制研究

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WebJul 14, 2024 · Forkhead box O (FOXO) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many … Web果蝇中影响dFOXO调控寿命功能的相关基因的鉴定. 【摘要】： Foxo作为转录调节因子家族中的一员,可参与多条重要的信号通路,介导下游靶基因的转录表达,从而在细胞分化、代 …

WebNov 24, 2024 · BmFoxO could upregulate the expression of BmPEPCK-2 by binding to the BmPEPCK-2 promoter. Moreover, overexpression of BmFoxO significantly increased the expression of autophagy genes ATG6/7/8 after infection with BmNPV, consistent with BmPEPCK-2. These results indicate that BmNPV downregulates transcription factor … WebFeb 5, 2024 · In addition, the expression of BmFoxO was altered, and it was found that reduced expression of BmFoxO (dsBmFoxO) downregulated the expression of BmPEPCK-2 and increased the viral fluorescence and content in silkworm embryonic cell line BmE cells, and vice versa. BmFoxO could upregulate the expression of BmPEPCK-2 by binding to …

WebMay 10, 2024 · Europe PMC is an archive of life sciences journal literature. WebIn this study, we demonstrated that the BmFoxO gene participates in the regulation of the cell cycle induced by 20-Hydroxyecdysone (20E) in BmN-SWU1 cells. The 20E blocks …

Web4.BmFoxO的靶基因筛选及其对寿命的影响BmFoxO表达水平的升高能够显著延长家蚕个体寿命已经得到了证实,然而其延长寿命的分子机制仍需要进一步研究。 由于BmFoxO属于转录因子,其在执行功能过程中需要通过调节下游靶基因的转录活性来实现,因此FoxO下游靶基因的 ...

WebJul 14, 2024 · BmFOXO mutants showed no deleterious effects during embryonic development. However, unlike WT larvae that molt four times prior to metamorphosis, the mutant larvae grew slower and molted only three times (Fig. 1 A).The mutants showed significant growth delay from the first to the third larval stage when compared with the … dorh hrvatskaWeb而人类目前只有2个长寿基因，FOXO3a和ApoE，很多抗衰老策略在复杂的衰老信号网络背景下，可能并不能影响FOXO3和ApoE的作用，因此难以延长人的寿命。. 此外，FOXO作 … rac-36np/ras-36njpWebBmFOXO. mutants. The results showed that the expression of the insulin receptor (InR) gene was reduced by 86%, whereas the serine/threonine kinase (Akt) and 4E-binding protein (4EBP) were up-regulated in mutants when compared with their expression in WT (Fig. 1. D. andsupplementalS2. B rac36qk1WebJan 31, 2024 · We also detected the expression of BmFoxO, which encodes an evolutionarily conserved integrator in lifespan regulation networks. We preliminarily … dorh kaznena prijavaWebJan 31, 2024 · The expression of BmFoxO was significantly elevated in the dietary restriction group on day 3 of the 4th instar and day 3 of the 5th instar, suggesting that BmFoxO contributes to dietary restriction-mediated lifespan extension. The RNA interference and overexpression of the BmFoxO gene significantly shortened and … rac-3706sWebDownload scientific diagram Mean lifespan, maximum lifespan, and BmFoxO expression in different silkworm strains. A. Survival curves for silkworm strains 18-115, 15 ... rac 39Webof BmFoxO was significantly elevated in the dietary restriction group on day 3 of the 4th instar and day 3 of the 5th instar, suggesting that BmFoxO contributes to dietary restriction-mediated lifespan extension. The RNA interference and overexpression of the BmFoxO gene significantly shortened and extended the silkworm adulthood, respectively. rac4005