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WebCymbalta does not have weight gain as a listed side effect. It does have weight loss as a possible but rare side effect. Any serotonin reuptake inhibitor (Cymbalta's a Serotonin-NRI) will contribute to feelings of hunger. Serotonin makes you … WebJan 20, 2015 · Among 2% of individuals that take Cymbalta, weight loss is a side effect. If you end up losing weight, there’s no telling exactly how much you’ll lose. Possible factors responsible for weight loss while on this drug include: decreased appetite, energy improvements, and a faster metabolism. WebAt least two commenters who reviewed the medication on a discussion board at EverydayHealth.com wrote that they had gained weight while using it. One person said she experienced steady weight gain up to more than 20 pounds. One person, however, reported seeing weight loss during Cymbalta use. Cymbalta’s effects on weight have been … floaters headache