Irf2bp2 cancer

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August undefined, 2024

WebNov 22, 2016 · IRF2BP2 is a downstream target of p53 and repressor of the cell cycle regulator NFAT1 (refs 7, 8). IRF2BP2 is fused to CDX1 as a result of the t (1;5) (q42;q32) … WebMar 8, 2024 · Instituto Nacional do Câncer. Mar 2011 - Oct 20154 years 8 months. Rio de Janeiro Area, Brazil. - Planned and executed experiments to support the development of my thesis project about NFAT1 ...

The Tumor Suppressor Interferon Regulatory Factor 2 …

WebJul 20, 2015 · IRF2BP2 is a cofactor modulating IRF2 and myocyte enhancer factor 2 (MEF2), transcription factors important for innate immunity and gene expression in macrophages. 8 – 12 Exposure of macrophages to bacterial lipopolysaccharide activates the M1 inflammatory phenotype, whereas exposure to interleukin (IL)-4 favors the M2 anti … WebIRF2BP2 is altered in 0.02% of all cancers with sarcoma, NOS, breast invasive ductal carcinoma, gastric adenocarcinoma, lung adenocarcinoma, and pancreatic acinar cell … can mobile home park owner deny sale of home

IRF2BP2 interferon regulatory factor 2 binding protein 2

WebMar 19, 2024 · All-trans-retinoic acid (ATRA), 45 mg/m 2 in divided doses daily until clinical remission, plus arsenic trioxide (ATO), 0.15 mg/kg IV daily until bone marrow remission; alternatively, ATO may be given in a dose of 0.3 mg/kg IV on days 1–5 of week 1 and 0.25 mg/kg twice weekly during weeks 2–8. In the ATRA-ATO regimen, an ATRA dose of 25 mg ... WebIRF2BP2_ENST00000366610 Sequences You can see various sequences for this gene: cDNA (ENST00000366609.3) Protein (IRF2BP2) Transcript and protein aligned … WebSep 25, 2015 · IRF2BP2 is required for the expression of the anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2). Restoring KLF2 in IRF2BP2-deficient macrophages … can mobi be converted to epub

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The novel tumor suppressor IRF2BP2 regulates Hippo pathway

WebMay 15, 2024 · Here, we identified a novel clinical variant, IRF2BP2 c.625_665del, from two members of a family with inflammatory conditions and investigated the function of IRF2BP2 and c.625_665del mutation in JAK–STAT pathway activation and inflammatory signaling. The levels of constitutive and cytokine-induced phosphorylation of STATs and total … http://english.cemcs.cas.cn/news/202411/t20241120_252214.html can mobile and pc play genshin togetherWebObjective: Primary central nervous system lymphoma (PCNSL) is a specific type of non-Hodgkin lymphoma with poor prognosis. The rare incidence of this disease and difficulty to obtain sufficient tissue material impede deep research into PCNSL. However, application of modern molecular techniques makes it possible to find biological characteristics … can mobileiron track you

"WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of … " - Irf2bp2 cancer

Irf2bp2 cancer

IRF2BP2 protein expression summary - The Human Protein Atlas

WebSep 20, 2024 · The conserved Hippo pathway regulates organ size, tissue homeostasis, and tumorigenesis. Interferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally … WebApr 25, 2024 · Abstract. The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2

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WebJul 6, 2024 · We identified the immune modulator IRF2BP2 as a selective AML dependency. We validated AML cell dependency on IRF2BP2 with genetic and protein degradation … WebIRF2BP2 is involved in 1 fusion, with the following gene: CDX1 (1 mutation in 4 samples) Drug sensitivity data Mutations in IRF2BP2 are associated with altered sensitivity to the following 10 drugs: Dactolisib Docetaxel SN-38 Show all See all drug sensitivity data for IRF2BP2. External links

WebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and … WebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid...

WebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... BREAST CANCER CARCINOID CERVICAL CANCER COLORECTAL CANCER ENDOMETRIAL CANCER GLIOMA HEAD AND NECK CANCER LIVER CANCER LUNG CANCER LYMPHOMA. WebMar 21, 2024 · IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Diseases associated with IRF2BP2 include Immunodeficiency, Common …

WebInterferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene. Function. This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding ...

WebNov 22, 2016 · IRF2BP2 is a downstream target of p53 and repressor of the cell cycle regulator NFAT1 (refs 7, 8). IRF2BP2 is fused to CDX1 as a result of the t (1;5) (q42;q32) in mesenchymal chondrosarcoma... can mobile phone batteries be replacedWeb癌症免疫疗法是生物医学界目前最热门的领域之一。近日，发表在《科学》杂志上的一项研究中，科学家们发现了一种参与肿瘤免疫逃逸行为的关键蛋白，它与“赫赫有名”的PD-L1蛋白的表达密切相关。这一名为Cdk5的关键蛋白及其相关信号通路有望成为免疫疗法的新靶点。 can mobi files be read on kindleWebMar 17, 2024 · The data show that IRF2BP2 is a novel target gene repressed by the YAP-TEAD transcriptional complex, and exhibits potent antitumor activity by inhibiting YAP activity. The researchers identify that IRF2BP2 interacts with VGLL4 and stabilizes the protein level of VGLL4, which leads to synergistic inhibition toward YAP. fixes and workarounds windowsWebSep 25, 2015 · In a recent issue of Circulation Research, Chen et al report that IRF 2–binding protein 2 (IRF2BP2) is a novel regulator of macrophage inflammation and lipid homeostasis that acts by maintaining anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2) expression, therefore reducing susceptibility to atherosclerosis 6 ( Figure 2 ). can mobile play with pc among usWebMar 29, 2024 · IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles. IRF2BP2 … fixes as a clock crossword clueWebIRF2BP2 INFORMATION. Proteini. Full gene name according to HGNC. Interferon regulatory factor 2 binding protein 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. IRF2BP2 (IRF-2BP2) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). fixes for hornbill security camerasWebJan 22, 2024 · IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction. Kouketsu T, Monma R, Miyairi Y, … fixes for maytag chest freezer lock