WebAlzheimer's disease (AD) is the most common type of senile dementia.The antiaging gene Klotho is reported to decline in the brain of patients and animals with AD. However, the role of Klotho in the progression of AD remains elusive. The present study explored the effects and underlying mechanism of Klotho in a mouse model of AD. WebJan 27, 2005 · In the current study, we presented strong evidence confirming the role of a common variant of KLOTHO, the KL-VS allele, in human longevity. Cross-sectional and …
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WebJun 5, 2014 · This study investigated polymorphisms of a metabolism-related gene, Klotho, and an inflammatory gene, IL6, for association with the aging process in a healthy Han Chinese population. A total of 482 healthy subjects were recruited and divided into aging and young groups according to chronological age and biological age. WebFeb 15, 2016 · The Klotho G-395A SNP and components of MetS In the whole population, the -395A allele carriers, compared with the control subjects, had significantly lower frequencies of high blood pressure (49.8 % vs. 66.3 %, p < 0.001) and hypertriglyceridemia (11.7 % vs. 19.2 %, p = 0.017).
WebJun 24, 2024 · It is involved in longevity 1, cardiovascular (CV) ... Hamajima, N. & Niwa, T. KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density ... Bone Mineral Density was measured using dual-energy X-ray absorptiometry (DXA, Hologic Inc. Bedford, MA, USA) at the lumbar spine, femoral neck, and total hip. All BMD measurements were performed by the same experienced technologist, following the recommendations by the International Society for Clinical … See more This study was based on data from the São Paulo Ageing & Health (SPAH) Study, which surveyed 65-year-old and older individuals living in a community in the … See more Each subject was interviewed by a physician and responded to a standard questionnaire designed to gather information about lifestyle, health behaviours, and … See more Osteoporotic fracture was defined as a fracture occurring at sites characteristic of bone fragility (e.g., the rib, spine, forearm, humerus, and femur) on fifty-year … See more Appendicular skeletal muscle mass (ASM) was measured by DXA: ASM relative to height and total fat mass were assessed. Relative ASM was derived by … See more
WebApr 16, 2014 · Indeed, many single-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic … WebJul 1, 2024 · Klotho, a longevity factor, enhances cognition when genetically and broadly overexpressed in its full, wild-type form over the mouse lifespan. Whether acute klotho treatment can rapidly enhance cognitive and motor functions or induce resilience is a gap in our knowledge of its therapeutic potential. Here, we show that an α-klotho protein ...
WebFeb 15, 2016 · To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and …
WebAug 30, 2016 · Klotho is the name of the Greek goddess who spins the web of time and regulates the span of life. In both humans and experimental animals, Klotho promotes longevity, while disturbances in Klotho ... alberto poveda martinez monovar alicanteWebMar 1, 2024 · Klotho polymorphisms have been previously associated with longevity (defined, depending on the study, as people over the age of 66, 75 or 93 years) in … alberto pozzatoWebApr 16, 2014 · Indeed, many single-nucleotide polymorphisms (SNPs) associated with longevity were identified in genes encoding proteins that take part in this metabolic … alberto pozasWebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney-specific ablation of Klotho which demonstrated the phenotype of global Klotho knockout mice. 21 The serum soluble Klotho was declined about 80% in those kidney-specific ... alberto pontilloWebNov 17, 2024 · In humans, total Klotho protein levels decline with age in serum, while single nucleotide polymorphisms have been identified in the klotho gene that correlates with reduced longevity and the pathophysiology of age-related disorders such as osteoporosis, coronary artery disease, and stroke ( 4 – 8 ). alberto pontiniWebOct 13, 2024 · Reduced expression of the Klotho gene or α-Klotho protein level are associated with a shorter lifespan and risk of neurodegenerative diseases, as well as … alberto pradesWebThis study correlated the VDR gene polymorphisms (FokI, ApaI, BsmiI, and TaqI) with frailty, computed by frailty index (FI), in 202 persons (127 women and 75 men, aged from 60 to 116 years), aiming to capture the involvement of vitamin D in the sex-frailty paradox. ... Klotho is a bona fide longevity gene that, if inactivated, generates a ... alberto pozas periodista