WebSide effects of phenytoin include sedation, a cerebellar syndrome, phenytoin encephalopathy, psychosis, locomotor dysfunction, hyperkinesia, megaloblastic anemia, decreased serum folate level, decreased bone mineral content, liver disease, IgA deficiency, gingival hyperplasia, and a lupus-like hypersensitivity syndrome. WebToxicokinetics. Phenytoin is slowly but nearly completely absorbed in the small intestine; oral bioavailability ranges from 70 to 100%. The drug is widely distributed in the body and …
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WebFeb 9, 2024 · Summary. Commonly reported side effects of phenytoin include: congenital anomalies. Other side effects include: hepatic necrosis, ataxia, confusion, constipation, … WebPhenytoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: difficulty falling asleep or staying asleep uncontrollable eye movements … taifun handwerker download
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WebJan 15, 2024 · The etiology of phenytoin-induced gingival enlargement (PIGE) is likely due to the direct effects of the drug and its metabolites on the gingival fibroblasts. Other factors which can contribute to PIGE include adrenocortical axis suppression, alterations in the metabolism of calcium, low serum folic acid levels, and suppression of the immune ... WebSep 4, 2024 · The chance of phenytoin suspension's side effects may be raised or how well phenytoin suspension works may be lowered. ... Take good care of your teeth. See a dentist often. Do not stop taking phenytoin suspension all of a sudden without calling your doctor. You may have a greater risk of seizures. Webdrug in the cerebrospinal fluid are proportional to the free plasma concentration. Phenytoin accumulates in the brain, liver, muscle and adipose tissue, where it is fixed to the endoplasmic reticulum of the cells [8]. Phenytoin is metabolized in main mode by means of the parahydroxylation at 5-(P-hydroxyphenyl)-5-phenyl hydantoin (HPPH), twice most prettiest